I don't think being married would have too much of an effect on things, as long as your s.o. knows what he/she is in for and is committed to giving you the time you will need. I am married and we have a 2 year old, which does make things somewhat harder... but not impossible. This is the best article I ever read on the subject:

http://steveblank.com/2009/06/18/epitaph-for-an-entrepreneur...