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>There are around 115 U.S. acetaminophen deaths per year, versus around 17k opioid analgesic deaths.

First, I said "overdoses", not "overdose deaths". There is a difference.

The source you cited doesn't make it clear whether the known opioid deaths did or did not involve acetaminophen. Since hydrocodone, oxycodone, codeine, dihydrocodeine, and tramadol are all combined with acetaminophen, I'd guess the intersection of the two sets is significant.

The FDA recognized this problem and cut the APAP dose in combination analgesics to a maximum of 325mg (compared with the recommended 500mg dose of APAP alone) in 2009. They did not restrict the opioid dosages because they weren't responsible for the toxicity.



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