The best way to make Helium 3 is with Deuterium fusion. Its a very interesting bootstrap question -- how do you build new reactors, if you have to have working reactors to generate fuel?

So really it's a mixed-mode D-D/3He-D reactor? How much more common are D-D reactions than 3He-D reactions while the reactor is running normally?

How much does the initial charge of 3He cost, given that the stuff costs $7,000 a gram?