Deliberately targeting non-combatants? No. Disregarding their safety? That's probably closer to the truth. But just because you are a non-combatant doesn't mean you aren't supporting combatants. And that's when tough decisions have to be made. It's a horrible choice that must be made.
Is it really a tough decision? A tough decision would be to put soldiers on the ground to do that. Killing someone in a far away country with very few chances that it will be reported looks like a rather easy solution.
As for WWII, http://en.wikipedia.org/wiki/Civilian_casualty_ratio#World_W...