I don't see how your example is related. Firstly, Stephan's description of the brain's role is that it regulates both appetite and metabolism. These mechanisms indirectly regulate fat storage.
Insulin of course would cause fat storage, but your example neither eliminates the other mechanisms, nor is a fault in the brain signalling system as it's an local injection. It's unrealistic to expect the system to have such a fine degree of control.
The role of insulin is to remove excess energy and funnel it into fat cells. That is of course why you see the weight gain. But that is only one part of the system.
As for your experiment, I can say it won't work on me - I typically eat until there is no food left, regardless of "fullness". In fact if I were at a buffet I would eat to actual physical fullness. Yet I do not have discomfort and I am still lean enough for me stomach muscles to show. I have stayed the same weight for the last 15 years. Thus, there has to be a regulation system, perhaps as proposed by Stephan.
Insulin of course would cause fat storage, but your example neither eliminates the other mechanisms, nor is a fault in the brain signalling system as it's an local injection. It's unrealistic to expect the system to have such a fine degree of control.
The role of insulin is to remove excess energy and funnel it into fat cells. That is of course why you see the weight gain. But that is only one part of the system.
As for your experiment, I can say it won't work on me - I typically eat until there is no food left, regardless of "fullness". In fact if I were at a buffet I would eat to actual physical fullness. Yet I do not have discomfort and I am still lean enough for me stomach muscles to show. I have stayed the same weight for the last 15 years. Thus, there has to be a regulation system, perhaps as proposed by Stephan.