Except that getting karma points is more difficult for people who comment/post in offpeak times (like on the other side of the world), so this system can essentially penalise them.
What is offpeak? Until a month ago, I was staying up until 6 in the morning Eastern Time, and there was never a lull in activity. Stories stay up for 24 hours very often, so even if you post while nobody's on, they still eventually come across your comment.
Well I'm about 14 hours ahead of east coast USA - I usually get to stories about 6-8 hours after they've started and my comments can most often be found down the bottom of threads and due to "group think" thats where they stay.
The other thing to do is to comment on new stories (which I do) but due to them not being as often trafficked those can also go unnoticed.
Generally, I can still get karma, but most often I get Karma by saying inane things or being early to a post. At most other times I'm shit-outta-luck.