There certainly can be. Reputation risk/being canceled, misinformation spreading, ethicial/legal issues depending on the topic, public opinion influence, authority problems, not understanding the community you are participating in, etc.
Seems like their comment engages a curious person to wonder how likely it might be. That's as much value as I generally expect to get from any comment.
If you're completely uninformed, why post at all? What value do you add to the conversation?