> If Ozempic is so great then how come our bodies don't just produce more GLP-1
This strays too far into appeal to nature teritory. Evolution made us fit to reproduce not to age.
As for "no free lunch" - we do have a lot of that in medicine historically speaking: iodine salt, clean water, vitamins (C, D), iron supplements, hormone theraphy, vaccines. The field of medicine is no stranger to free lunch.
By "no free lunch" I meant that any change which evolution could easily have led to, but didn't, has likely not been evolutionarily advantageous for long enough or with great enough selective pressure to happen. Emphasis on "easily", "likely", and "long enough"/"great enough".
I don't think evolution could easily have solved most dietary deficits, manufactured clean water, prevented every endocrine condition, or designed vaccines for us. I'm not even sure what that last one would mean! These things are a nearly-free lunch because we live in industrial economies that can ship oranges around the world and build dams, but they're not an evolutionary free lunch. (And the loss of vitamin C production is argued to be an adaptation to starvation, too, just like we're arguing that lower GLP-1 is an adaptation to starvation: https://academic.oup.com/emph/article/2019/1/221/5556105)
Exactly! Further for evolution in the larger picture, it is actually necessary for living beings to die at some point, because of overpopulation. Survival instinct of the individual is only necessary to achieve enough reproduction. Death after reproduction age is necessary for evolution.
This strays too far into appeal to nature teritory. Evolution made us fit to reproduce not to age.
As for "no free lunch" - we do have a lot of that in medicine historically speaking: iodine salt, clean water, vitamins (C, D), iron supplements, hormone theraphy, vaccines. The field of medicine is no stranger to free lunch.