Besides all the animation stuff, a prominent application was for the Space Shuttle. NASA bought a bunch of Symbolics XL Lisp machines, to process HDTV video feeds to monitor the Space Shuttle launches. From 1990:
"Recently the National Aeronautical and Space Administration (NASA) used Symbolics' high-definition technology to analyze HDTV video images of the Discovery launch in real-time. This high-definition system enabled NASA engineers to get an instant replay of critical launch systems. The engineers were able to enhance and enlarge high-resolution images of the lift-off in order to analyze the condition of and spot potential problems with space shuttle tiles."
NASA's STS seemed to be full of very eclectic setup - I mean we had Symbolics machines running video analysis, Amigas running telemetry, I think Explorer's might have been involved in early days of Hubble scheduling software (that now runs on Unix with X11), etc. etc.
"Recently the National Aeronautical and Space Administration (NASA) used Symbolics' high-definition technology to analyze HDTV video images of the Discovery launch in real-time. This high-definition system enabled NASA engineers to get an instant replay of critical launch systems. The engineers were able to enhance and enlarge high-resolution images of the lift-off in order to analyze the condition of and spot potential problems with space shuttle tiles."