Nothing if you don't take it personally. There's 'not trusting' in the sense of recognizing that most processes or people are unreliable, including yourself and there's 'not trusting' in the sense of thinking everyone's out to get ya or not living up to your expectations.
The second one largely has to do with ego and is the one that creates insecure people who usually hold others to different standards than themselves, the first is just a realistic view of the world and thus very useful
Yet another very important portion of reality that science hasn't gotten around to yet. Perhaps we'll find the answer a bit further out in the universe, or deeper inside matter.