We do not have firsthand experience with the Nuclera's chip based system. But there are some key differences based on what we can find online:

- their system uses display technology based backpanel from Eink to activate the electrodes. The display itself could be the consumable that is disposed after each run (we are not sure from their website). The technology is suited for manipulating very small volumes. Looks like they have picked applications that span enzymatic DNA synthesis and protein eexpression

- the Callisto system uses standard PCBs and plastic surface that interfaces with the droplets. The PCBs are not disposed after each run, while the plastic surface is. We can also handle a large dynamic range of volumes in liquids making it suitable for more standard molecular biology workflows.