I was just reading the other day about the history of x-ray crystallography, and how the Fourier transforms that were the domain of the supercomputers of the 1940's-1950's were, prior to that, months-long labors of human calculators [0]. It's a provocative history! I wonder what aspects of present life will seem, in hindsight, to have been "Sisyphean" labors—once they're no longer needed.

[0] https://journals.iucr.org/a/issues/2008/01/00/sc5015/ ("Busting out of crystallography's Sisyphean prison: from pencil and paper to structure solving at the press of a button[...]")