Probably not. I live in a parallel universe where `npx tsc` does nothing except spit out available arguments. I can first `npx tsc --init`, after which `npx tsc` converts the TS files into corresponding JS files, but that puts you no further ahead. You still need tooling to do anything with those files. In a universe where `npx tsc` knows what tool you need every time you run it – something completely incomprehensible in this universe – it is undoubtedly also impossible for those in that understand what we go through in this one.
What in practice causes the most pain for mé are the various module formats in combination with TS. Just getting my test runner (Mocha) and Node and the bundler and... to work with TS and the chosen module format is always _not_ fun. Combined with package updates that break the current working solution because they now natively support es modules. I hope these problems will all disappear in the future, but I'm somewhat sceptical.
And TS is slow - not C++, Haskell and Rust slow, but still. But I never used TS/Node for anything big (backendy), but just small frontends and VS Code extensions, where the time of getting everything set-up to work takes a relatively larger part of the "actual" work.