Some c modules are incompatible with PyPy. Two common ones are psycopg2 (PostgreSQL driver) and pyodbc (ODBC driver). There are alternatives that work but they don't have quite as many features (psycopg2cffi and pypyodbc). Ansible also runs slower in PyPy than CPython.
I tested this with a playbook that installs a set of scripts and dependencies on a server. In all there's ~30 tasks. It takes ~1 minute using CPython 3.10 and ~1.5 minutes using PyPy 3.10 (v7.3.12). Ansible says libyaml is installed in both runtimes so that's ruled out. I wonder if it's the difference in interpreter start-up time, and it accumulates over time as Ansible starts so many Python processes as it runs its tasks.
