you mean comparing before and after COVID? longitudinal is better, but those take more time to produce so these kinds of studies come first. Also, almost everyone has COVID now, so it's even harder to do that.
It's a lil crazy that people are so willing to say well we let it rip, and because of that, we can ignore any problematic findings because we can't compare current populations easily and across long periods of time. The most likely hypothesis, based on known mechanisms and studies, is that yes, COVID infection will fuck you up. This is the case with most human pathogenic viruses, even ones that have a "mild" initial presentation like EBV (multiple schlerosis), CMV (wears down immune system in old age), Chickenpox (shingles), HPV (cancer), or HIV (immune dysfunction).
The fun thing is, COVID sometimes has an acute life-threatening aspect as well, so it is probably double the fun.
No, I just mean that the study observed an increase in incidence of autoimmune disorders which cannot be explained by COVID because of the window of collection.
> Over the study period, age and sex standardised incidence rates of any autoimmune diseases increased (IRR 2017–19 vs 2000–02 1·04 [95% CI 1·00–1·09]).
I completely agree with COVID both being generally dangerous even outside of the acute infection and that it has likely caused a substantial increase in autoimmune disorders. This study just indicates that there are likely other environmental factors at play as well that predate COVID.
"Method A cohort was selected from German routine health care data covering 38.9 million individuals. Based on documented diagnoses, we identified individuals with polymerase chain reaction (PCR)-confirmed COVID-19 through December 31, 2020. Patients were matched 1:3 to control patients without COVID-19. Both groups were followed up until June 30, 2021. We used the four quarters preceding the index date until the end of follow-up to analyze the onset of autoimmune diseases during the post-acute period. Incidence rates (IR) per 1000 person-years were calculated for each outcome and patient group. Poisson models were deployed to estimate the incidence rate ratios (IRRs) of developing an autoimmune disease conditional on a preceding diagnosis of COVID-19."
Sorry I missed this - I was referring to the study in the OP, not the study you linked. I agree that the study you linked indicates a higher incidence of autoimmune conditions among those who had covid.
Not sure, but the difference between a measured amount of bound spike protein and an uncontrolled amount of fully functional spike + other evil proteins like those derived from orf8 and orf6 means I fully expect the virus to be the main problem here.
I don’t know if you know this but the vaccine is not a measured amount of bound spike protein at all. It’s mRNA that gets transcribed over and over - each mRNA molecule creates many spikes. Exactly how many depends on many factors in your body.
When I’m at a PC again I will link you to some studies showing cases where it exceeds the amount you’d expect in a natural infection and there’s documented cases where it continues weeks after injection unlike the virus which doesn’t last that long in healthy young people.
That's fair, but it's a fixed amount of RNA and RNA degrades. The virus can continually create new RNA. COVID has been shown to persist in a fraction of patients, so it will continue for months or years. I don't see how these situations are comparable. Again, the vaccine spike is edited to be bound in the pre-fusion conformation whereas the natural spike is flexible and can bind to ACE2 and expose additional internal inflammatory sites.
"Young, healthy people" makes enormous assumptions about a tiny slice of the population. After one or more COVID infections, they may acquire the dreaded "co-morbidities" that a huge fraction if not a majority or supermajority of the population have. Despite how we like to think we have personal control over our circumstances, in this situation, we do not. It is a collective effort and we are failing to control transmission.
Vaccines are part of this, as are masking with N95 respirators, testing, air cleaning, paid sick leave, scientific isolation and quarantine periods, etc. I am hopeful that with targeted or universal air cleaning combined with partial population immunity (maintained via periodic vaccine updates) and paid leave, we can push the reproduction number below one. This is a very serious crisis that is worsening in some ways, but we are acting like the physical environment has no bearing on our lives if we think positively.
https://www.livescience.com/covid-19-linked-to-40-increase-i...