I'm willing to wager there are zero subject matter experts today who could do such a thing. The biggest reason is that the computational methods that would let you design such a thing in-silico are not there yet. In the last year or two they have improved beyond what most people believed was possible but still they need further improvement.
I am not a subject expert here at all so I don’t know if I understand exactly what you mean by “methods that would let you design such a thing in-silico”, but there was a paper[0] and interview with its authors[1] published a year ago about a drug-development AI being used to design chemical weapons.
