It’s worth trying because it could be that there is a chemical mechanism rather than it being the trip. For example ketamine can ‘cure’ people of alcoholism and depression at doses that do not produce ‘profound’ experiences or at doses that do. Having said that I accidentally had a ‘therapy’ session while completely off my tits on LSD and it helped with things that I’d not previously been helped with on other trips.

The issues at hand are complex, it’s worth trying to control just to find out what the mechanisms are.

Also apologies for all of the air quotes in this ‘comment’