I really struggled with it, during a time when I was reading many large or difficult books: Don Quixote, Moby Dick, The Quran. I like the idea of it, but couldn't get into it. I was perhaps considering the audio book instead as that might inject a bit more life into it.
Honestly, it's worth it if you love language and literature at all. Joyce did something extraordinary here.
There's a text called the Bloomsday Book that you may find useful if you get lost.