I love frame.work as a concept, but it's definitely not a "proven" concept at the moment. The company could very well go under or choose not to support upgrading the laptop.
Even assuming Framework shuts down tomorrow and destroys their existing stock of replacement parts and the specs for making new ones, I would argue that you can at the very least assume permanent availability of RAM, SSD, Display (it uses a commodity panel), fan, and battery (there are knockoff batteries for much more obscure laptops).
I would assume that keyboards, trackpads, etc. will also be available as some laptops bite the dust and are scavenged for parts.
Whether the motherboard/CPU will actually be upgradeable obviously remains to be seen. The 11th Gen CPUs get a lot of flak, but they have good single-core performance which will make them suitable for general use for a long time.
It's at least equally upgradeable as the first ThinkPads with soldered on CPUs, which by today's standards is still pretty good - and if framework deliver on their promises, then it will be even better. But either way the baseline isn't bad.
> I would argue that you can at the very least assume permanent availability of RAM, SSD, Display (it uses a commodity panel), fan, and battery
I mean, you can buy a new-ish Thinkpad where you can replace/upgrade all of those things. You get great compatibility and most hw/sw compatibility bugs are already known and have workarounds. Framework has to have some other value propositions as well besides being able to replace things you mentioned.
As I said, that's the absolute worst-case scenario.
I don't own one personally, but reviews have been overwhelmingly positive so presumably it does have something to offer beyond replaceability. (disclaimer: some people on HN seem to have had some driver issues on Linux on theirs)