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Vitamins are catalysts of chemical reactions. When you speed up reactions dependent on, say, B1 - you should also be sure that adjacent reactions are fastened up. Otherwise, this may cause an imbalance which can be disastrous or even fatal.

The same rule goes to minerals - when you take vitamins, the reaction speeds increase and they start to consume significantly more substrates causing electrolyte disbalances, which can be disastrous and even fatal. That's why you have to make sure that you take enough of Mg, K, P when you get vitamins as well.



As an example I will show how taking his dose riboflavin might increase the need for Zinc and Magnesium.

To turn Riboflavin into FMN using an enzyme called RFK, which needs zinc and magnesium as cofactors:

https://www.uniprot.org/uniprot/Q969G6

The it turns FMN to turn into FAD using FLAD1, which needs Magnesium as a cofactor.

https://www.uniprot.org/uniprot/Q8NFF5




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