I don't have wrist pain, but I sometimes have pain in my index fingers. I have been trying for a long time to figure out a good solution and have tried several keyboards as a result. It seems like keeping my wrist rested in one spot causes my index fingers to extend to reach keys that are one column/row over. Floating my wrists allows me to move my whole arm for those out of reach keys, reducing the impact on my index fingers. I currently use a low profile Nyquist from keeb.io and while I enjoy it, I don't think it does anything in particular to address my issue other than being split (which I love). Keeping my hands floating is the easiest when I am standing and my desk is leveled with my elbows.