I've run a Mumble server for my friends group for a while. It worked fine and had a couple of nice features, e.g. that anyone could create a temporary channel and move there with some people and when they all quit the channel would be removed again. This way everyone could organize as they see fit.

But the audio setup and tweaking was a nightmare. It was the biggest problem for every participant to tune and tweak their levels in a way that would work good, it was very, very frustrating.

The chat was also super barebones and of course no way to stream video.