Curiously I find the opposite: home-row typing, or using wrist rests etc and keeping my hands static, cause me quite bad RSI. Instead I use a very "floating" style of typing where my hands move very freely over the keyboard, kinda like playing the piano.
That makes sense to me. You get repetitive stress injury from repetitive overuse of small and weak muscles, not from using bigger muscles (like your shoulders) to move your hands/arms in non-strenuous ways.
I've always felt the same way. My fingers naturally want to spread out, so pulling them close enough together to rest on the home keys causes a lot of tension.