Create a new profiling environment based on the template you're interested in, making sure "Choose a profiling template for:" is set to "Your Computer > All Processes." Next, in the top-left of the window, where it says "Your Computer > All Processes", click on All Processes. Select Choose Target... and navigate to your binary and hit Choose. Then hit the red circle to begin recording. This will launch a new instance of the specified binary and profile it.

This may not work for binaries that set PT_DENY_ATTACH, though.

Thanks :)

Yes, it’s possible. In the menu with all the processes, pick the option “Choose Target”. It’s kind of an annoying UI, but it works.

Another option is to use `xcrun xctrace` to get a recording from the command line, which can then be opened in Instruments.