I don't know about Gmail in the browser because I access it via IMAP and SMTP, but I have noticed that the browser process that's associated with tab that has the Google voice page open will occasionally start consuming a lot of CPU and memory resources to the point that I have to terminate the process.
This never happens with Thunderbird and is even less likely to happen with a TUI client like Mutt.
This never happens with Thunderbird and is even less likely to happen with a TUI client like Mutt.