When I first moved to Seattle in the early 2000's I remember seeing signs on I-5 with a number to report people violating the HOV lanes. Call '764-HERO'. A local band started called '764-HERO' and I thought that was so clever given that only local people would get the joke.
When I first moved to New Mexico, I was puzzled by the billboards which featured a stern cop and the word "ENDWI". What the hell's an endwi? Eventually I realized it was just the (weird) slogan from the state anti-drunk driving (Driving While Intoxicated) campaign.
In Aus I liked the roadsigns with random trivia questions along the really straight part of the road from Bundaberg to Brisbane, trying to keep your mind occupied so that you stay awake.
Now there are slogans like "Drive. Text. Die." They still haven't found a slogan/campaing to get people to put their phones down that has been as effective as "Don't Mess With Texas". Sometimes, no matter how much you wish it so, a slogan just won't take off.