Guix is still a general purpose operating system running on a general purpose computer. You should be able to run any software on it that is GNU or Linux compatible.
If you don't want to go through the pain of installing it outside of a package manager, that's fine, but that's not "locking you out", it's putting the blame where it belongs: the proprietary ISV.
If you don't want to go through the pain of installing it outside of a package manager, that's fine, but that's not "locking you out", it's putting the blame where it belongs: the proprietary ISV.