How much of it is cultural? Were the indigenous peoples of the Americas particularly murderous (I seem to remember depictions of human sacrifice where large cages were filled with people to be burned)? How much of it came from the Spanish inquisition/conquistador culture? These are the questions I ponder whenever related subjects come up, but unfortunately I have no answers.
The Aztecs--and I specifically mean Aztecs here and not the Mexica in general--were probably some of the most profligate sacrificers in human history. But outside of them, the pre-Columbian Americans don't seem to be unusually inclined to human sacrifice, especially in comparison to the rest of the world. The difference is that they were first contacted by European society at a time when they still practiced religious beliefs that included human sacrifice while the Europeans had forgotten just how much they had sacrificed humans a millennium earlier.
From my experience visiting the Mayan highlands in Guatemala, I’d say the indigenous people are generally wonderful human beings dealing the best they can with a hard situation.
They’re so far away from the days of human sacrifice, it’s like asking if white people are naturally violent because of the 30 years war.