A 64-bit host, running a 32-bit guest, itself running a 16-bit app. This scenario can run into the VME bug.

Any exploitation scenarios here?

Could you package a trimmed down version of that stack up and cause a reliable crash on Ryzens operating on a more typical platform?

Maybe it becomes a bit of a rube goldberg malware at that point...

The first part of that is optional, and the last part of that is also optional.