The only real issue I run into is clipboard wonkiness when console apps integrate the clipboard (nvim+twmux).
Beyond that, it has a ton of features - none of which I use since I manage my sessions with tmux. So I guess it's mostly a matter of not wanting a sledgehammer when the right tool is a finishing hammer?
I use nvim inside Konsole/Yakuake and I don't have any issue with the clipboard.
"+p and "+y works fine
Also Shift+Inst and Shift+Supr keeps working fine.