>"Investigators were blinded to allocation during experiments
and outcome assessment, except for rare instances where blinding was not possible."
Not saying this should mar the study or anything, but I wonder what that could mean.
Edit: It appears I spoke too soon and this does mar the study. I thought they always waited for natural death, but no:
"mice were injected twice a week with AP or vehicle until they became moribund or died of natural causes."
They don't explain the methods or data (how many, etc) regarding these moribund mice anywhere either. The lack of effective blinding procedures combined with this undefined "moribund" state is actually a huge red flag.
Not saying this should mar the study or anything, but I wonder what that could mean.
Edit: It appears I spoke too soon and this does mar the study. I thought they always waited for natural death, but no:
"mice were injected twice a week with AP or vehicle until they became moribund or died of natural causes."
They don't explain the methods or data (how many, etc) regarding these moribund mice anywhere either. The lack of effective blinding procedures combined with this undefined "moribund" state is actually a huge red flag.