What he is saying is that highways encourage people to build everything more spread out, including residences, offices, and stores. He’s not claiming this is problem for the stores per se, or that it inherently changes the relationship between people and stores.

The problem is the increased money and land spent on transportation, the increased pollution, the unfriendliness of the system for pedestrians / anyone who can’t drive, and the inability to build mass transit to cover the same areas.