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Meanwhile biodome couldn't keep an artificial ocean from acidifying.



OH yea, I confused it with the movie name.

Surprisingly, the wikipage fails to mention it was a failed experiment and doesn't mention the ocean issue at all.


Well wasn't that like the first real attempt on this & to a degree a non-optimal one at that ?

Its not like sustainable extraterrestrial habitats will not be needed elsewhere anyway, so it should be hopefully long established technology (by the lava tube settlers of the Moon or the Oneil Cylinder bunch from L3) when you do the first interstellar ship.


LLM agents don't know how to shut up and always think they're right about everything. They also lack the ability to be brief. Sometimes things can be solved with a single character or line, but no they write a full page. And, they write paragraphs of comments for even the most minuscule of changes.

They talk at you, are overbearing and arrogant.


I expect a lot of the things people don't like ("output too long, too many comments in code") are side effects of making the LLM good in other areas.

Long output correlates with less laziness when writing code, and higher performance on benchmarks due to the monotone relationship between number of output tokens and scores. Comment spam correlates with better performance because it's locally-specific reasoning it can attend on when writing the next line of code, leading to reduced errors.


Just add to the prompt not to include comments and to talk less.

I have a prompt document that includes a complete summary of the Clean Code book, which includes the rules about comments.

You do have to remind it occasionally.


You can, but I would expect code correctness to be reduced, you're removing one mechanism the model uses to dump local reasoning immediately prior to where it's needed.


With that logic, I should ask the AI to _increase_ the amount of comments. I highly doubt the comments it generates are useful, they're usually very superficial.


Perhaps not useful to you, but they are the only way the LLM has to know what it is doing.

It has to reason about the problem in its output, since its output comprises almost the entirety of its "awareness". Unlike you, the LLM doesn't "know" anything, even superficial things.

In some sense it's like us when we are working on a problem with lots of novel parts. We usually have to write down notes to refer to in the process of solving the problem, except for the LLM the problem is always a novel problem.


I usually use huge context/prompt documents (10-100K tokens) before doing anything, I suppose that helps.

I’ll experiment with comments, I can always delete them later. My strategy is to have self-documenting code (and my prompts include a how-to on self-documenting code)


But that information is scattered. It's helpful for the LLM to cluster and isolate local reasoning that it can then "forget" about when it moves on to the next thing. Attending to nearby recent tokens is easy for it, looking up relevant information as needle in a haystack every single time is more error prone. I'm not saying asking it to remove comments will lead to a catastrophic drop off in performance, maybe something like a few percent or even less. Just that it's not useless for pure benchmaxxing.


I have added it in the guidelines doc for Junie and that won't stop it. It can't help itself - it needs to write a comment every three lines, no matter the language it's writing in.


Hah the need to add comments is pretty resilient, that’s true.


I was trying out sonnet 4 yesterday and it spent 15 minutes changing testing changing etc just to get one config item changed. It ended up changing 40 files for no reason. Also kept trying to open a debugger that didn’t exist and load a webpage that requires auth.

They’re far from perfect that’s for sure.


I don’t think anyone seriously is claiming perfect. The thing is all of AI is moving 5 times faster than any disrupting tech before it.

We went from proof reading single emails to researching agentic coding in a year.

It should have been five.


For reference in case anyone is wondering, it is based on:

https://github.com/152334H/tortoise-tts-fast

The developer of tortoise tts fast was hired by Eleven labs.


'was'. I departed almost half a year prior to v3's release this week.


Where are you now? What are you working on?


The former does not imply the latter.


Does this mean when they grow up, their own offspring will also have this defect and require a correction? And, if so, does this mean it is now introducing this defective gene into our gene pool?

I know this is an issue with caesarean section. It is becoming more prevalent because those who require it are surviving, making it more likely to happen in their offspring.


We get half of our genes from each of our parents. So unless this person has the extremely unlikely misfortune of partnering with someone else with the same rare mutation, their offspring would only have a 50/50 chance of inheriting their copy of this gene. There are also medical procedures (PGD) to bring that chance to virtually 0%.


We don't get 50/50 of distinct genes from our parents - it is more like 30/70 and can be even 10/90. The whole DNA ratio in this equation is irrelevant, as we all have 99% of the same DNA. Also, in real world, one parent will consistently give more of their distinct genes than other parent and most likely that consistent gene part will have that single mutation that they would hope to avoid, but contain best genes that the parent can offer. Children from multiple partners could be a solution as it is a different math...

>>>There are also medical procedures (PGD) to bring that chance to virtually 0%. For that one gene only. DNA is a math of sum of genes and from what I have read humans are not better than nature(which is not perfect, but very basic) at selecting best specimens of eggs and sperm, but yes - whatever they have picked - PGD might be able to root out that one single mutation, and introduce variety of other mutations or miss good genes from other combinations. So, it all depends...


Also parents who are both carriers have a 25% chance of making a sick child, a 25% chance of making a non carrier and non sick child, and a 25%+25% chance of making non sick yet carrier child. So they already have a 50% chance of making children who'll survive and yet be carriers of the disease. I guess this will increase this to 75%. But you have to evaluate this in connection with the rapid increases in genetic treatment options, which decreases the issues.


> know this is an issue with caesarean section. It is becoming more prevalent because those who require it are surviving

You state this as a fact and I've heard it as a strong hypothesis, but I wasn't aware of much evidence to confirm it?


"The cesarean delivery rate increased from 5% in 1970 to 31.9% in 2016. This sharp increase can be attributed to various factors, including changes in maternal age, medical advancements allowing more complicated pregnancies to proceed, and evolving obstetric practices. In 2022, the United States recorded more than 3.66 million births, most of which resulted from spontaneous or induced labor. Labor dystocia remains the most common indication for primary cesarean delivery. Globally, cesarean delivery rates continue to rise, and reducing unnecessary cesarean procedures remains a priority in the United States, where 32.2% of all births in 2022 were cesarean deliveries."

https://www.ncbi.nlm.nih.gov/books/NBK546707/

"If this trend continues, by 2030 the highest rates are likely to be in Eastern Asia (63%), Latin America and the Caribbean (54%), Western Asia (50%), Northern Africa (48%) Southern Europe (47%) and Australia and New Zealand (45%), the research suggests."

https://www.who.int/news/item/16-06-2021-caesarean-section-r...

Note: Coincidentally, WHO's article I've linked is lamenting that Sub-saharan Africa only had 5% cesarean due to less availability of the procedure. It is their perspective that the increase in percentages is a good thing and indicates progress, instead of being concerning. And, they find Sub-saharan Africa's low numbers concerning, instead.

Side Note: I also found lots of interesting articles which I haven't posted here, about epigenetic side effects caused by caesarean deliveries like leukemia, illnesses and other genetic issues. But, that seems out of scope for your question. You can make a quick search and find these, though.

"A female-to-female familial predisposition to caesarean section was observed. It could be caused by biologic inheritance, primarily working through maternal alleles and/or environmental factors. The results imply that both mechanisms could be important."

https://pubmed.ncbi.nlm.nih.gov/18540028/

"Large-scale epidemiological studies indeed evidence that women born by C-section are more likely to deliver by Caesarean than women born vaginally, owing primarily to genetic rather than social factors."

https://www.pnas.org/doi/10.1073/pnas.1712203114


> Another Note: Also, ironically WHO's article I've linked is lamenting that Sub-saharan Africa only had 5% cesarean due to less availability of the procedure. It is their perspective that the increase in percentages is a good thing and indicates progress, instead of being concerning. And, they find Sub-saharan Africa's low numbers concerning, instead.

Pretty sure their perspective is that "saving the lives of mothers and babies" indicates progress.

> While a caesarean section can be an essential and lifesaving surgery, it can put women and babies at unnecessary risk of short- and long-term health problems if performed when there is not medical need.

> Rather than recommending specific target rates, WHO underscores the importance of focusing on each woman’s unique needs in pregnancy and childbirth.

> WHO recommends some non-clinical actions that can reduce medically unnecessary use of caesarean sections, within the overall context of high quality and respectful care:


Yes, that's what they're indicating. And, it is saving lives. I myself was cesarean section, as was my mother. I wouldn't be here without it.

That's the potential conundrum, if it turns out to be vastly increasing the need to save those lives than in the past due to a evolutionary pressure on the gene pool. If the WHO is right and we're going to start seeing 50 - 63% increases by 2030, what's in store for the human race if this rate of expansion keeps up?

Will we reach a time when no one can be naturally born and almost our entire race has to be conceived in external gestation devices or cease to exist? And, when we reach that point will we look with concern towards Africa and wonder at how sad it is they're still conceived naturally.

Edit: I don't have the answers. I'm not sure what we should do to course correct or if we need to. But, it is definitely something that should be looked into before it is too late, if it isn't already. And, that is why I brought it up in the context of this breakthrough, to ask if we've considered similar consequences. And, if we have a way to mitigate them if that turns out to be the case.


> Edit Edit: I can't reply to your comment below I think we've hit the leaf end of this post. But, to reply to your question are c-sections replacing natural births or are they just becoming more common? The research I've cited has indicated this is a genetic transfer among female-to-female births of a need for more cesareans.

To reply after a certain number of child comments, you have to open the comment by clicking the timestamp thing

I'm also afraid I don't understand your response. Can you elaborate?


Thanks, I replied to your other comment.


Are c-sections replacing 'natural' births, or are they simply becoming more common because we have the expertise? There is a difference


The research I've cited has indicated this is a genetic transfer among female-to-female births of a need for more cesareans.

"A female-to-female familial predisposition to caesarean section was observed. It could be caused by biologic inheritance, primarily working through maternal alleles and/or environmental factors. The results imply that both mechanisms could be important."

https://pubmed.ncbi.nlm.nih.gov/18540028/

"Large-scale epidemiological studies indeed evidence that women born by C-section are more likely to deliver by Caesarean than women born vaginally, owing primarily to genetic rather than social factors."

https://www.pnas.org/doi/10.1073/pnas.1712203114


> "Large-scale epidemiological studies indeed evidence that women born by C-section are more likely to deliver by Caesarean than women born vaginally, owing primarily to genetic rather than social factors."

Interesting. That makes sense. I wonder if the type of research being pursued in TFA might be helpful.

In any case, I also have to wonder whether it's necessarily a bad thing. I quoted 'natural' births earlier because... what is natural? The amount of medical knowledge and technology that go into births doesn't seem very "natural" to me, and this has advanced through the ages to where we are now - where we, rightfully so, look sadly on areas where lack of such technology and knowledge result in more preventable deaths of babies, even if their methods are more "natural"

Of course, to be honest, I'm not very familiar with the pros and cons of c-sections vs natural births - particularly when the question is whether to have a child. I suppose that, given the choice between a c-section and the alternatives, most women will opt for a c-section, and as you point out, that means their daughters likely will have to as well

So what might the solution even look like, apart from exploring the aforementioned gene-editing technology - or other technology - to prevent the genetic factor of c-sections? I would hope that "don't offer c-sections" is not a serious option. "Stop having kids" is one I'd personally suggest, but that's obviously not a sane global solution either.

It's an interesting problem I'd be curious to hear more about - as I said, I'm not very familiar with this.


Interesting - thank you!


Research is inconclusive regarding what exactly causes this increase.

We know that infants are generally larger than 50 years ago and one of the factors which trigger birth is the inability of the mother's metabolism to support further growth of the fetus.

That, combined with the fact that all over the world availability of nutrition is much better than half a century ago points to this being the culprit.


How can they pass it on when they don't have the defect any more?


Gene editing is still pretty crude in terms of delivery.

Just because you can hit some germ-line cells in the liver, for example, doesn’t imply you’ll have good penetration into the reproductive organs.

We can’t zap people and change all their DNA at once, unless we can intervene at the point it’s just a few cells.


The DNA was only edited in the liver. But by the time this baby grows up and starts a family, we'll probably be able to fix that, too.


That's a bold claim. The baby is 9 month old, there are many things that can still go wrong with this experimental treatment.

Hopefully not, but even then no one can say what progress will make science in the next 25 years.

Back in the 50's people thought we would be driving in flying car in 2000.


Four years ago highly-upvoted /r/SanFrancisco comments said self-driving taxis were decades away: https://old.reddit.com/r/sanfrancisco/comments/nbjsij/real_r...


12 upvotes...

You can't compare that to gene-editing treatments, that's two completely different level.

Self driving car were always almost feasible, 20 years ago top gear made cars you could drive with controller like kids do with toy cars. We already had camera and computer, it was just a matter of raw CPU performance and software development..


we have all the CPU performance we need and all software development we need and self-driving cars are driving around in roughly 0.00785% of world’s cities :)


If by "they" you mean their gametes, those were not edited. Only a component of their corporal shell was modified.


It only affects some cells, not the whole body.


they could CRISPR his relevant reproductive cells, this general topic is an important subject of discussion


Ah, yes - few million of them. Simple task for sure, if the liver is functioning as testes.



This is something I have never seen for decades - a troll that posts links to his own quotes...

We met again.


I think the solution is going to take the form of synthetic mirror neurons, if we can ever successfully replicate those.


I'm surprised no one is mentioning Brave. They refuse to take Chrome's change.


Because Brave is a scam browser that nobody should be using. There are other chromium forks that don't scam you. Brave's history of scumbag actions isn't anything new.


That cult is kind of the opposite tho, they were looking forward to the impending hell of AGI and thought they were doing things that would get on the good side of the evil overseer AI of the future. If anything they weren't going crazy over it they felt comforted.


They are too rational for religion but desperately need meaning (or whatever) so they convinced themselves they could literally talk directly to god (after he exists he will simulate their exact personalities at this exact moment in time).


These are the people too smart for regular cults?


The unfortunate truth is that everyone can be manipulated and everyone can be conditioned.

It just takes time and/or the right circumstances.

This includes propaganda.


They probably believe(d) they are/were but cults exploit a lot of fundamental human biases, desires and weaknesses. Pretty much anyone could fall in with a cult given the right approach. IMO all believing you're too smart for a cult gets you is a blind spot that lets the right cult sneak up on you even easier.


In the past... we'd just eat the eggs, get the flu, spread it about a bit, take a day / week off work, go back to work. You know, normal life. Now we overreact and just cull all the eggs and/or chickens and jack the prices up. It seems kind of weak tbh. You're never going to purify the world and make it perfect. One day someone in the future is going to say, "Ew they ate real food instead of processed food pellets?" unironically.

Then a disease will arrive that will make the entire population vanish because their immune systems never had to interact with anything.


Is this really the point OpenAI wants to start debating? When OpenAI steals everyone's data, it is fine. Right? But, let us pull the ladder up after that.


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