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BillionToOne (YC S17) | Menlo Park, CA; on-site or hybrid (US only) | Full-time BillionToOne is ranked at the top 5% of Y Combinator companies with close to $400M in funding. In June 2024, we closed a $130M Series D resulting in a company valuation of over $1 billion. This funding has come from prestigious global institutional investors, including Hummingbird, Adams Street Partners, Neuberger Berman, Baillie Gifford, and Premji Invest. We have developed a DNA molecular counter that increases cfDNA diagnostic resolution by over 1,000x. Our first product, Unity, is the first and only non-invasive prenatal test that can directly screen an unborn baby and assess its risk for: common and severe recessive gene disorders; chromosomal abnormalities; fetal sex; and fetal antigens from a single tube of blood from the pregnant mother. This greatly improves the quality of care and is on its path to becoming the next standard-of-care.

Our software stack includes Python/Django, React/Typescript, Terraform, AWS, and many other standard tools. We're a small, but nimble software team that prioritizes rapid iteration and continuous feedback to evolve our product. As a biotech company, we inherently need to always work cross functionally. If you enjoy this style of work, please reach out!

We're hiring software engineers, bioinformatics engineers, and many other roles. You can email me directly at kwu@billiontoone.com with your resume or apply through the links below.

- Senior Software Engineer, Frontend: https://job-boards.greenhouse.io/billiontoone/jobs/436548500...

- Bioinformatics Associate, Prenatal: https://job-boards.greenhouse.io/billiontoone/jobs/434501600...

You can view all open roles on our careers page: https://billiontoone.com/careers/open-positions/.


If an admin is reading, the same position(s) have been posted for since May last year ( look at the greenhouse links from here: https://news.ycombinator.com/threads?id=kevinwuhoo ).

If a potential applicant is reading, they ignore all correspondence after hour long intro meet


This reminds me of the Katamari Hack back in the day when bookmarklets were more popular. Surprised that it's still fully functional including the music considering it was released in 2011!

[1]: http://kathack.com/


Incredible. Plays music and generates a snowball that absorbs page contents as one touches/clicks around a webpage.


Unfortunately only on HTTP sites since the assets aren't served over HTTPS. Though thankfully it's easy enough to grab the resources and re-host them behind HTTP.

And, of course, you can test it out on that website since it's served over HTTP.


BillionToOne (YC S17) | Menlo Park, CA; on-site or hybrid (US only) | Full-time BillionToOne is ranked at the top 5% of Y Combinator companies with close to $400M in funding. In June 2024, we closed a $130M Series D resulting in a company valuation of over $1 billion. This funding has come from prestigious global institutional investors, including Hummingbird, Adams Street Partners, Neuberger Berman, Baillie Gifford, and Premji Invest.

We have developed a DNA molecular counter that increases cfDNA diagnostic resolution by over 1,000x. Our first product, Unity, is the first and only non-invasive prenatal test that can directly screen an unborn baby and assess its risk for: common and severe recessive gene disorders; chromosomal abnormalities; fetal sex; and fetal antigens from a single tube of blood from the pregnant mother. This greatly improves the quality of care and is on its path to becoming the next standard-of-care.

Our software stack includes Python/Django, React/Typescript, Terraform, AWS, and many other standard tools. We're a small, but nimble software team that prioritizes rapid iteration and continuous feedback to evolve our product. As a biotech company, we inherently need to always work cross functionally. If you enjoy this style of work, please reach out!

We're hiring software engineers, bioinformatics engineers, and many other roles. You can email me directly at kwu@billiontoone.com with your resume or apply through the links below.

- Senior Software Engineer, Frontend: https://job-boards.greenhouse.io/billiontoone/jobs/436548500...

- Senior Bioinformatics Engineer, Prenatal: https://job-boards.greenhouse.io/billiontoone/jobs/449603100...

- Director, AI Engineering: https://job-boards.greenhouse.io/billiontoone/jobs/449575500...

- Director of IT: https://job-boards.greenhouse.io/billiontoone/jobs/455290000...

You can view all open roles on our careers page: https://billiontoone.com/careers/open-positions/.


BillionToOne (YC S17) | Menlo Park, CA; on-site or hybrid (US only) | Full-time

BillionToOne is ranked at the top 5% of Y Combinator companies with close to $400M in funding. In June 2024, we closed a $130M Series D resulting in a company valuation of over $1 billion. This funding has come from prestigious global institutional investors, including Hummingbird, Adams Street Partners, Neuberger Berman, Baillie Gifford, and Premji Invest.

We have developed a DNA molecular counter that increases cfDNA diagnostic resolution by over 1,000x. Our first product, Unity, is the first and only non-invasive prenatal test that can directly screen an unborn baby and assess its risk for: common and severe recessive gene disorders; chromosomal abnormalities; fetal sex; and fetal antigens from a single tube of blood from the pregnant mother. This greatly improves the quality of care and is on its path to becoming the next standard-of-care.

Our software stack includes Python/Django, React/Typescript, Terraform, AWS, and many other standard tools. We're a small, but nimble software team that prioritizes rapid iteration and continuous feedback to evolve our product. As a biotech company, we inherently need to always work cross functionally. If you enjoy this style of work, please reach out!

We're hiring software engineers, bioinformatics engineers, and many other roles. You can email me directly at kwu@billiontoone.com with your resume or apply through the links below.

- Senior Software Engineer: https://job-boards.greenhouse.io/billiontoone/jobs/436548500...

- Senior Bioinformatics Engineer, Oncology: https://job-boards.greenhouse.io/billiontoone/jobs/449603100...

- Senior DevSecOps Engineer: https://job-boards.greenhouse.io/billiontoone/jobs/449820000...

You can view all open roles on our careers page: https://billiontoone.com/careers/open-positions/.


BillionToOne (YC S17) | Menlo Park, CA; hybrid or remote (US only) | Full-time

BillionToOne is ranked at the top 5% of Y Combinator companies with close to $400M in funding. In June 2024, we closed a $130M Series D resulting in a company valuation of over $1 billion. This funding has come from prestigious global institutional investors, including Hummingbird, Adams Street Partners, Neuberger Berman, Baillie Gifford, and Premji Invest.

We have developed a DNA molecular counter that increases cfDNA diagnostic resolution by over 1,000x. Our first product, Unity, is the first and only non-invasive prenatal test that can directly screen an unborn baby and assess its risk for: common and severe recessive gene disorders; chromosomal abnormalities; fetal sex; and fetal antigens from a single tube of blood from the pregnant mother. This greatly improves the quality of care and is on its path to becoming the next standard-of-care.

Our software stack includes Python/Django, React/Typescript, Terraform, AWS, and many other standard tools. We're a small, but nimble software team that prioritizes rapid iteration and continuous feedback to evolve our product. As a biotech company, we inherently need to always work cross functionally. If you enjoy this style of work, please reach out!

We're hiring software engineers, a product designer, and many other roles. You can email me directly at kwu@billiontoone.com with your resume or apply through the links below.

- Senior Manager, Software Engineering: https://job-boards.greenhouse.io/billiontoone/jobs/444633700...

- Senior Software Engineer, Digital Experiences: https://job-boards.greenhouse.io/billiontoone/jobs/436548500...

- Lead Product Designer: https://job-boards.greenhouse.io/billiontoone/jobs/401388700...

- Senior Manager/Director of IT: https://job-boards.greenhouse.io/billiontoone/jobs/442815200...

- Senior Bioinformatics Scientist: https://job-boards.greenhouse.io/billiontoone/jobs/405155200...

You can view all open roles on our careers page: https://billiontoone.com/careers/open-positions/.


BillionToOne | Menlo Park, CA; hybrid or remote (US only) | Full-time

BillionToOne (YC S17) is ranked at the top 5% of Y Combinator companies with $300M+ in funding from top VC firms. We have developed a DNA molecular counter that increases cfDNA diagnostic resolution by over 1,000x. Our first product, Unity, is the first and only non-invasive prenatal test that can directly screen an unborn baby and assess its risk for: common and severe recessive gene disorders; chromosomal abnormalities; fetal sex; and fetal antigens from a single tube of blood from the pregnant mother. This greatly improves the quality of care and is on its path to becoming the next standard-of-care.

Our software stack includes Python/Django, React/Typescript, Terraform, AWS, and many other standard tools. We're a small, but nimble software team that prioritizes rapid iteration and continuous feedback to evolve our product. As a biotech company, we inherently need to always work cross functionally. If you enjoy this style of work, please reach out!

We're hiring software engineers, a director of bioinformatics, and many other roles. You can email me directly at kwu@billiontoone.com with your resume or apply through the links below.

- Senior Software Engineer, Digital Experiences: https://boards.greenhouse.io/billiontoone/jobs/4365485005

- Director of Bioinformatics, Prenatal: https://boards.greenhouse.io/billiontoone/jobs/4321605005

- Senior Bioinformatics Scientist, Prenatal: https://boards.greenhouse.io/billiontoone/jobs/4398144005

You can view all open roles on our careers page: https://billiontoone.com/careers/open-positions/.


BillionToOne | Menlo Park, CA; hybrid or remote (US only) | Full-time

BillionToOne (YC S17) is ranked at the top 5% of Y Combinator companies with $300M+ in funding from top VC firms. We have developed a DNA molecular counter that increases cfDNA diagnostic resolution by over 1,000x. Our first product, UNITY, is the first and only non-invasive prenatal test that can directly screen an unborn baby and assess its risk for: common and severe recessive gene disorders; chromosomal abnormalities; fetal sex; and fetal antigens from a single tube of blood from the pregnant mother. This greatly improves the quality of care and is on its path to becoming the next standard-of-care.

Our software stack includes Python/Django, AWS, React/Typescript, Terraform, and many other standard tools. We're a small, but nimble software team that prioritizes rapid iteration and continuous feedback to evolve our product. As a biotech company, we inherently need to always work cross functionally. If you enjoy this style of work, please reach out!

We're hiring software engineers, a director of bioinformatics, and many other roles. You can email me directly at kwu@billiontoone.com with your resume or apply through the links below.

- Senior Software Engineer, Digital Experiences: https://boards.greenhouse.io/billiontoone/jobs/4365485005

- Senior Software Engineer, Platform: https://boards.greenhouse.io/billiontoone/jobs/4305991005

- Senior/Staff Software Engineer, Oncology (Full-Stack): https://boards.greenhouse.io/billiontoone/jobs/4304858005

- Director of Bioinformatics, Prenatal: https://boards.greenhouse.io/billiontoone/jobs/4321605005

You can view all open roles on our careers page: https://billiontoone.com/careers/open-positions/.


BillionToOne | Menlo Park, CA; hybrid or remote (US only) | Full-time

BillionToOne (YC S17) is ranked at the top 5% of Y Combinator companies with $300M+ in funding from top VC firms. We have developed a DNA molecular counter that increases cfDNA diagnostic resolution by over 1,000x. Our first product, UNITY, is the first and only non-invasive prenatal test that can directly screen an unborn baby and assess its risk for: common and severe recessive gene disorders; chromosomal abnormalities; fetal sex; and fetal antigens from a single tube of blood from the pregnant mother. This greatly improves the quality of care and is on its path to becoming the next standard-of-care.

Our software stack includes Django, AWS, React/Typescript, Terraform, and many other standard tools. We're a small, but agile software team that prioritizes rapid iteration and continuous feedback to evolve our product. As a biotech company, we inherently need to always work cross functionally. If you enjoy this style of work, please reach out!

We're hiring software engineers, a director of bioinformatics, and many other roles. You can email me directly at kwu@billiontoone.com with your resume or apply through the links below.

- Senior/Staff Software Engineer, Digital Experiences: https://boards.greenhouse.io/billiontoone/jobs/4305991005

- Senior Software Engineer, Platform: https://boards.greenhouse.io/billiontoone/jobs/4326884005

- Director of Bioinformatics, Prenatal: https://boards.greenhouse.io/billiontoone/jobs/4321605005

You can view all open roles on our careers page: https://billiontoone.com/careers/open-positions/.


This study was done using data from the UK Biobank [1] which is registered as a non-profit. Participants were also volunteers only.

[1]: https://en.wikipedia.org/wiki/UK_Biobank


It's quite a fun thought experiment to think about how you might avoid this bias.

Send Blackhawk helicopters to collect samples by force? Was there bias in the selection technique? What about the people genetically predisposed to avoid the Blackhawk helicopters? We'd need multiple collection methods, and still need to retain an unbiased distribution. You can continue until you get to "we should set up global search patterns so that no human can escape our dystopian DNA collection". And even then you're still biased by population effects owing to the probability that there is a genetic population who have been predisposed to suppress their own genetic population at this point in time.

Gosh, it sounds like a fever dream.


Why not take DNA from randomly selected trashcans, since discarded waste can be used to steal DNA

https://www.usatoday.com/story/news/nation/2023/07/20/police....


Even then, you'd bias your sample toward people who use those trash cans (people who live near the trash cans you selected, people who don't litter, people who spend a lot of time in public if they are public trash cans, etc.)


Bias in surveys is an interesting and hard problem to think about, but not really a new one. Seems to me like the typical demographic control approaches would work here too.


10x Genomics | Pleasanton, CA & San Francisco, CA | Remote (US Only) or Onsite

We're a biotech company that creates software, hardware, and chemistry to accelerate humanity's understanding of biology. Scientists have used our products to make discoveries in antibiotic resistance, autoimmune disease, cancer, immunology, and more.

Our software team creates products that enable scientists to analyze complex biological data. For example, a scientist may use our software to determine precisely which cell types could be cancerous. We utilize Go, React, Typescript, and Electron to create intuitive visualization and web applications. We've written our data pipelines using the Numpy/Scipy/Pandas stack, and we're making increasing use of Rust [0].

We've always been and continue to be remote-friendly. I'm currently hiring for a Senior Frontend Engineer: https://careers.10xgenomics.com/careers/job?pid=171814105834. Feel free to email a resume to me directly: kevin.wu@10xgenomics.com.

I look forward to hearing from you, and good luck with your search!

[0]: https://www.nature.com/articles/d41586-020-03382-2


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