Looks like over the five years they were there they founded it, got it funded, and got them through the first car creation and delivery: the roadster. Pretty big deal, I didn’t actually know that much about these two but that’s incredibly impressive. Thanks for giving me a reason to do some research on the topic.
They were out by the time roadster entered production. Musk provided the first financing round, and became pretty involved since the beginning of designing the roadster. Pretty good story on it here[1]
David Sinclair is a social media influencer more than anything else. His insistence on life extension through lifestyle alone is telling, because it's so easy to sell to the general public. Except this doesn't work and can't work — if an organism has a goal to destroy itself, which it does as part of its aging program, it WILL destroy itself, no matter how much you change its environment. You need to overwrite that internal goal state to truly cure aging which can't be done through any manner of lifestyle interventions.
Effective advocacy begins with letting go of the assumption that everyone already knows about the things you know about. I'm sure this person is well known within the bioscience community, but this is the first time I'd heard of him or his model.
> This technique also extended the lifespan of mice with a premature aging condition by about 40%.
Why is it always like this? Even "in mice" I think they always start with an animal that has been genetically modified to age faster or show some trait of aging and then cure that, as opposed to taking a normal healthy mouse and extending its age by 40%, no?
i love these comments. i never have a problem with comments where people are drawing on something they experienced. i treasure those comments. its funny because every other comment makes me feel like shit. like the world has gone to shit. and i make a lot of them.
its funny that you would think that those ads were targeted to you. television was so insanely monolithic. it was a shared experience. everyone thought the same thing. the idea of targeting anyone in particular with television seems silly today…
people are so naive. AI is a matter of national security now. its over. they exposed civilians to nuclear radiation for the nuclear bomb. and you think the state would let this get in the way of the AI arms race which they are anxiously anticipating? nope
exactly. nobody knows what some completely neglected or overlooked line of research will result in. this is why we should ban all research. its very possible that a seemingly innocuous research could result in AGI that will make humans obsolete and enable perpetual dictatorships and other nightmares. or result in a bomb that is very cheap and simple to make that unleashes enough energy to destroy the world in one shot, thus dooming us all. almost all of the worlds problems could be solved without new research. world hunger and war is not a technology problem. so doesnt it make the most sense to stop researching?
im so sad ireland shut down their golden visa program. im looking forward to building a portfolio of passports so i dont have to deal with the shit head border agents anymore.
i think the topic of salt is misunderstood. ancient people didnt eat as much and they worked more and harder and also didnt have access to air conditioning. sweating more would deplete electrolytes and entering into dietary ketosis frequently would lead to a major decline of electrolytes. i think ancient people needed salt because they would get sick without it. but eveyone says its because they liked the taste
Considering their diets, which were very high in carbohydrates (not sugars though) compared to modern diets that seems highly unlikely. Can you actually ever enter "ketosis" if you're mainly eating bread and other grain products?
> i think ancient people needed salt because they would get sick without it. but eveyone says its because they liked the taste
They needed salt because there weren't that many other ways to preserve food. I doubt this has much to do with taste. Also modern people need salt too..
> ancient people didnt eat as much
That's debatable. According to our records medieval people did sometimes eat quite a lot. I guess the problem is that it varied a lot. You either had too much or to little food all of the time.
ancient rome and medieval europe are really different. you can enter ketosis every day on a diet of carbohydrates by eating one or two times a day, eating less or engaging in exercise would make that ketosis deeper and longer. all of this could have applied to most people until relatively recently.
because they were much less fat than us, had almost none of the diseases we have that are all really metabolic dysfunction/diabetes at their root, and the general price and availability of food has only been getting better…
What does that have to do with ketosis? You can eat a lot of carbs and not be fat...
> had almost none of the diseases we have that are all really metabolic dysfunction/diabetes at their root
True. Unless you were rich. Even heard of gout? But yeah probably somewhat accurate for the whole population. But again, not much to do with ketosis.
I mean is there any evidence even today that someone whose diet is primarily (~80%) grain and other plant products with a lot of carbohydrates can enter ketosis even when practicing "intermittent fasting" while consuming ~2000-3000 calories per day (e.g. the estimate for standard Roman soldier daily rations is 3,000-4,000)? Seems impossible...
not really. its extremely well established science. you dont seem to have much experience with this topic. ketosis saved my life in 2019 and ever since then ive been learning as much as i can about ketosis and its medical applications
Not sure what you mean by that - at a time when people were largely self-sufficient and working the land, they obviously consumed enough calories for the work they were doing. The food may not have been great (a lot of bread!), but there would generally have been enough of it unless having to tough out the winter after a poor harvest.
There was also a very practical use/need for salt as a food preservative, specifically for storing meat over the winter. Certainly this was the case in the middle ages in Britain, but maybe not in the more southernly parts of the roman empire with warmer climates where food production may have been more year-round.
Yes it was. That hypothesis about ketosis is very wacky and not backed by any evidence. Premodern diets were very high in carbohydrates compared to modern ones....
