with your knowledge as a pathologist, would you agree that the success of this approach depends on the quality of the biopsy (i.e. obtaining a sample that faithfully represents the entire volume of tissue being investigated)? From my experience with prostate cancer screening research I know that biopsy scoring of prostate tumors can be very inaccurate compared to pathology scoring after a prostatectomy.
Not the OP, but a pathologist in training. Yes, quality is essential because depending on how the sample is prepared the image can be very difficult to interpret. Biopsy scoring of prostate tumors is difficult because a lot of the scoring takes into account features that may not appear on the biopsy because of insufficient sampling.
